Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple
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Methods: In this randomised, placebo-controlled, double-blind, phase 3 trial, done in 209 sites in 29 countries, we randomly assigned patients 2:1 with untreated locally recurrent inoperable or metastatic triple-negative breast cancer using a block method block size of six and an interactive voice-response system with integrated web-response to pembrolizumab 200 mg every 3 weeks plus chemotherapy nab-paclitaxel; paclitaxel; or gemcitabine plus carboplatin or placebo plus chemotherapy.
A randomized control trial found that and had similar efficacy, and reported no significant increase in adverse events with bevacizumab.
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